有氧运动对鼠杏仁核点燃进程的影响

Effect of aerobic physical exercise on amygdala-kindling development

目的 分析急性和慢性有氧运动对鼠杏仁核电刺激点燃进程的影响。方法 第 1组 (急性组 ,n=10 )有氧运动 1次 (游泳 2 h) ,运动后 1min给予电刺激点燃 ;第 2组 (慢性组 ,n=10 )接受有氧运动训练 (每天游泳2 h,共 45 d) ,然后与第 1组同样处理 ;第 3组 (n=10 )为对照组。各组均给予电刺激点燃 ,直到出现 级发作。结果 慢性组与另两组相比 ,达到 级发作所需电刺激的次数增多 ,具有统计学意义。与对照组相比 ,急性组和慢性组达到 级发作所需时间更长 ,并且在 级的痫性行为后放电时程短。结论 慢性运动可阻碍鼠的杏仁核点燃进程。

Objective To analyze the acute and chronic effects of aerobic physical exercise on kindling development. Methods The first group(acute group,n=10) was submitted to a daily bout of aerobic exercise(2 hours' swimming in the pool) and kindling stimulated 1 minute after exercise. The second group(chronic group,n=10) was submitted to an aerobic training program(2 hours' swimming in the pool everyday for 45 days) and then the same procedure as the first group. And the third group(n=10) served as control. All groups were kindling stimulated until they reached stage Ⅴ of kindling. Results The number of stimulations required to reach stage Ⅴ was statistically higher for the chronic exercise group compared to the acute exercise group and the control group. A longer time spent in stage Ⅰ and a shorter after discharge duration in stage Ⅰ were observed in the acute and chronic exercise groups compared to the control group. Conclusion Chronic physical exercise inhibits development of amygdala kindling in rats.