早期刺激干预对改善新生儿缺氧缺血性脑病预后的研究

The study on early intervention improving prognosis of neonatal hypoxic ischemic encephalopathy

目的 探索早期刺激干预对新生儿缺氧缺血性脑病 (HIE)预后的影响。方法 将 96例中、重度 HIE患儿随机分为两组 ,干预组 2岁前给予感知觉刺激、视听刺激、主动及被动肢体训练等早期干预措施 ,6个月前配合药物治疗 ,对照组 6个月前给予同样的药物治疗。结果 利用《Bayley婴儿发育量表》进行评估 ,1.5岁、2 .5岁时干预组精神发育指数 (MDI)及运动发育指数 (PDI)显著高于对照组 ,2 .5岁时异常率显著低于对照组。结论 早期刺激干预可以预防及降低 HIE后遗症的发生。

Objective To explore the effect of early intervention on improving the prognosis of neonatal hypoxic ischemic encephalopathy(HIE). Methods 96 cases with middle or serious level of HIE were randomly divided into two groups. Infants of intervention group were treated by the methods of sense perceptual stimulation,visual and auditory stimulation,initiative and passive body training before 2 years old. Both intervention and control groups were given the same medicine treatment before 6 mouths. Results At the age of 2 and 3,average scores of mental and physical development indexes which were estimated by using Bayley scales of infant development of early intervention group were significantly higher than those in control group. Abnormal rate of that group was lower than that of control group. Conclusion Early intervention is benefit to the prevention of the sequelae of HIE.