妥泰对West综合征患儿免疫功能的影响

Effects of topiramate on immunological function in patients with West syndrome

目的 观察妥泰对 West综合征患儿的免疫功能的调节作用。方法 采用流式细胞术对 West综合征患儿妥泰治疗前后外周血淋巴细胞亚群比例和血清免疫球蛋白进行检测 ,观察其动态变化 ,并与 2 5例正常婴儿比较。结果 经妥泰治疗后的 T辅助细胞与治疗前比明显下降 ,接近对照组。治疗前后 B细胞与对照组相比明显下降。治疗后 NK细胞与治疗前相比明显上升。治疗前后的 Ig A与对照组比明显下降。治疗后 Ig G与治疗前比明显上升已接近对照组。结论 妥泰可能通过调节免疫功能的作用 ,达到控制 West综合征发作。

Objective To explore the regulatory effect of topiramate on immunological function in patients with West syndrome. Methods Flow cytometry was applied to measure the proportion of lymphocytic subsets in peripheral blood in infants with West syndrome before and after topiramate treatment and 25 normal health infants. Results CD 4 and NK cell were markedly increased after topiramate treatment compared to before treatment(P<0.05) as well as control group. CD 19 and IgA were significantly decreased before and after topiramater treatment compared to control group (P<0.001,<0.05 respectively). Conclusion Treatment with topiramater can regulate immunological function in patients with West syndrome and proven to help control seizures.