胃腺癌局部淋巴结树突状细胞对转移和预后的影响

Dendritic cells of regional lymph node in relation to metastasis and prognosis of gastric cancer

目的 研究胃腺癌局部淋巴结中树突状细胞 (DC)对转移和预后的影响。方法 将S - 1 0 0蛋白作为DC特异性标记物 ,应用S -P免疫组化方法检测胃腺癌局部淋巴结中DC的数量和分布。结果 转移组淋巴结中DC较非转移组明显增多。在 57例转移组中 ,DC显著者 1 8例 ,5例生存率 55 .56 % ;DC不明显者 39例 ,5年生存率 2 3 .0 8%。 30例非转移组中 ,DC显著者 1 9例 ,5年生存率 73 .68% ;DC不明显者 1 1例 ,5年生存率 36 .36 %。经 χ2 检验 ,在上述两组中 ,DC显著者的转移和 5年生存率较DC不明显者差异均有显著性意义 (P <0 .0 5)。

Objectives To study the degree of dendritic cells (DC) of regional lymph nodes in relation to metastasis and prognosis of gastric cancer.Methods S-100 protein as the marker of dendritic cells was stained immunohistochemically in regional lymph nodes of gastric cancer.Results The degree of DC in metastatic group is much higher than that of non-metastatic group. In 18 of 57 metastatic group whose DC marked, the five-year survival rate was 55.56%.While 39 with DC less degree, the five-year survival rate 23.08%(P<0.05). Quite similar data were obtained from 30 non-metastatic group.Significantly higher five-year survival rate was observed in those with marked DC than those with less degree.Conclusions The degree of DC in regional lymph nodes of gastric cancer was closely correlated metastasis and prognosis.