传染性软疣样皮损表现的播散性隐球菌病2例

Two cases of disseminated cryptococcosis resembling molluscum contagiosum

报告2例播散性隐球菌病。除系统累及表现外,皮损为传染性软疣样丘疹,组织液、血液及脑脊液检查找到隐球菌,皮损和淋巴结组织病理学检查见孢子。提示当发热性疾病伴传染性软疣样皮损时,应警惕隐球菌感染。避免误诊和延误诊断的关键是提高对本病的认识和对可疑病例做真菌检查。

Two cases of disseminated cryptococcosis were reported. Beside systemic involvment, the skin lesions were papules resembling molluscum contagiosum. Cryptococcus neoformans could be found in skin lesion, blood and CSF samples. The histological study of skin lesion and lymph node revealed numerous encapsulated budding yeast forms. It suggests that physicians should think of cryptococcosis in febrile patients who are presented with skin lesions resembling molluscum contagiosum. The key points to avoid misdiagnosis and delayed diagnosis are earlier recognition and laboratory identification of the fungus in suspected patients.