摘要
目的 探讨血管紧张素Ⅱ受体拮抗剂氯沙坦 (Losartan)对高血压病患者血尿酸的影响。方法 采用前瞻性分析研究 ,将 6 0例高血压病患者随机分为两组 ,每组 30例。Losartan组 :给予Losartan 5 0mgqd ;西拉普利 (Cilazapril)组 ,给予Cilazapril2 5mgqd ;疗程 4周 ,观察治疗前后血尿酸的变化。结果 与基础值相比 ,Losartan组血尿酸明显降低 ,P <0 0 1,西拉普利组血尿酸轻度降低 ,但无统计学差异。结论 Losartan治疗高血压在降压同时具有降低血尿酸的作用。
Objective To observe the effect of angiorensin Ⅱ receptor antagonist on serum uric acid among the hypertensive patients.Methods 60 hypertensive patients were randomly divided into two groups.Losartan group(30 cases),Losartan 50mg qd;Cilazapril group(30 cases),Cliazapril 2.5mg qd.The course of treatment was four weeks.Serum uric acid was measured before and after treatment.Results Compareal with the besical value,serum uric acid decreased significantly(P<0.01) in Losartan group,but not in Cilazapril group(P>0.05).Conclusion Losartan can not only decrease the blood pressure but also subdue serum uric acid in hypertensive patients.
