摘要
目的:了解钙拮抗剂的不良反应情况。方法:检索1992～1999年7月《中国药学文摘》药物不良反应项下收载的国内医药期刊30种,文献共计113篇,对7种常用钙拮抗剂的166例不良反应原始资料进行记载、统计分析。结果:166例药物不良反应中硝苯地平62例(37.35％),占第一位,氟桂利嗪51例(30.72％),占第二位,尼莫地平20例(12.05％)占第三位;主要不良反应的发生率依次为中枢神经系统48例(28.92％),心血管系统26例(15.66％),皮肤反应21例(12.65％),局部水肿18例(10.84％)。除2例死亡外,其余164例经停药对症治疗均痊愈。结论:166例患者中50岁以上老年人112例(67.5％),多患心脑血管疾病,对常规剂量的钙拮抗剂反应敏感,应注意调整用药剂量和观察患者的临床表现,以确保用药安全。
Objective: To understand ADR induced by calcium antagonists. Method: Medical literature was retrieved from Chinese Pharmaceutical Abstracts (1992-1999) including 113 articles of 30 journals for ADR occurrence after calcium antagonist treatment. Results: Among 7 calcium antagonists causing ADR in 166 cases nifedipine came first (62 cases, accounting for 37.35% ), followed by flunarizine (51 cases, 30.72%) and nimodipine (20 cases, 12.05%) .ADR of 48 cases (28.92%) located in central nervous system, then 26 cases (15.66% ) in cardiovascular system, and 21 cases (12.65% ) in skin. Except for 2 deaths, 164 cases all recovered after discontinuation of the calcium antagonists and start of the expectant treatment .112 cases ( 67.5 % ) were the elderly over 50. Conclusion: Most of elderly patients suffering from cardio - cerebro - vascular diseases were susceptible to calcium antagonists and should be put in close attention clinically with the adjusted doses.
出处
《药物不良反应杂志》
2002年第3期154-156,共3页
Adverse Drug Reactions Journal
