Tourette综合征患儿脑电图遗传学特征研究

Genetic features of EEG abnormality in children with Tourette syndrome

目的 :探讨抽动秽语综合征 (Tourette综合征 ,TS)患儿及其父母的脑电图 (EEG)改变在生物遗传学上的意义。方法 :对 2 5例TS患儿及 5 0例父母进行 2hEEG监测研究。结果 :TS患儿父母的EEG异常率 (6 4 % )明显高于其抽动障碍发生率 (2 8% ) (P <0 .0 1) ,EEG异常的TS患儿及其父母的EEG异常率显著高于EEG正常的TS患儿的父母(P <0 .0 5 ) ,TS患儿双亲EEG异常也有较高比率 ,不同性别TS患儿父母间比较EEG异常没有明显差异。结论 :通过EEG检查 。

Objective To investigate the biogenetic significance of EEG abnormality in Children with Tourette syndrome (TS) and their parents. Methods EEG monitoring was carried out for 2 hours in 25 children with TS and their parents. Results The rate of EEG abnormality was significantly higher than the incidence of tic disorders in parents of TS children. The rate of abnormal EEG in parents of TS children with abnormal EEG was significantly higher than that in parents of TS children with normal EEG. EEG abnormality had no significant differences in parents of males and those of females. Conclusion EEG examination further indicates that Tourette syndrome has an inherit able tendency.