rCBF显像在PD,AD和OPCA中的应用

Application of rCBF imaging in PD, AD and OPCA

目的 :评价局部脑血流 (简称rCBF)显像在帕金森病 (简称PD)、阿尔茨海墨病 (简称AD)和橄榄桥脑小脑萎缩 (简称OPCA)中的诊断和鉴别诊断价值。方法 :分析PD ,AD和OPCA的rCBF显像放射性分布特点 ,寻找三种疾病的放射性分布规律。结果 :rCBF显像对PD ,AD和OPCA诊断的灵敏度分别为 88 4 % (38 4 3) ,95 8% (2 3 2 4 )和 85 7%(30 35 ) ;PD的放射性分布特点为 :大脑皮质 (2 5 4 3)、基底神经节 (2 1 4 3)、丘脑 (18 4 3)放射性降低 ;AD的分布特点为 :双侧大脑皮质 (17 2 4 )对称性放射性降低 ;OPCA的分布特点为 :大脑皮质 (17 35 )、小脑 (14 35 )、基底神经节 (14 35 )和丘脑 (10 35 )放射性降低。结论 :rCBF显像能灵敏地诊断PD ,AD和OPCA ,根据各自不同的放射性分布特点可进行鉴别诊断。

Objective To evaluate the diagnosis and differential diagnosis of rCBF imaging in Parkison's disease (PD), Alzheimer's disease (AD) and olivopontocerebellar atrophy (OPCA). Methods The characteristics of the radioactive distribution of rCBF imaging in PD, AD and OPCA were analyzed, and the laws of the radioactive distribution were identified. Results The sensitivity of rCBF imaging in PD, AD and OPCA was 88.4% (38/43), 95.8% (23/24), and 85.7% (30/35) respectively. The characteristics of the radioactive distribution were that the radioactivity decreased in the cerebral cortex(25/43), basal nuclei (21/43) and thalamus (18/43) in PD, that the radioactivity decreased in the bilateral cerebral cortex (17/24) in AD, that the radioactivity decreased in the crerebral cortex (17/35), cerebellum (14/35), basal nuclei (14/35) and thalamus (10/35) in OPCA. Conclusion rCBF imaging could sensitively diagnose PD, AD and OPCA, and also could differentially diagnose them according to their different characteristics of the radioactive distribution.