摘要
目的:调查1999～2000年北京和湖北地区金黄色葡萄球菌临床分离株的耐 药性状况。方法:采用K-B纸片扩散法进行抗菌药物活性试验。结果:（1）甲氧西 林耐药金黄色葡萄球菌（MRSA）的分离率存在地区差异;（2）北京地区和湖 北地区金黄色葡萄球菌的标本来源以伤口分泌物和呼吸道标本为主,在呼吸道 标本分离的金黄色葡萄球菌中,北京地区59.2％（161/272）、湖北地区39.9％（105/263）为MRSA菌株;（3）对于氯霉素,庆大霉素,红霉素,环丙沙星和复方磺胺 甲恶唑,湖北地区MRSA的多重耐药谱主要为氯霉素,庆大霉素,红霉素,环 丙沙星和复方磺胺甲 唑（20.6％）和氯霉素,环丙沙星,红霉素,庆大霉素（9.1％）,而北京地区则以氯霉素,环丙沙星,红霉素,庆大霉素（14.4％）和氯 霉素,环丙沙星,红霉素,庆大霉素（8.4％）为主;（4）北京的甲氧西林敏感 金黄色葡萄球菌（MSSA）对临床常用抗生素氯霉素、庆大霉素、环丙沙星和 复方磺胺甲 唑有较好的敏感性,湖北地区的MSSA除复方磺胺甲 唑外对氯 霉素、庆大霉素和环丙沙星也有较好的敏感性。结论:北京和湖北地区MRSA表 型多重耐药谱存在差别,MRSA和MSSA对抗生素耐药性也有不同。
OBJECTIVE: To investigate the antimicrobial resistance of clinical isolates of Staphylococcus aureus during a 2 period of 1999-2000. METHODS: Disc diffusion test (K-B method) was used to study the antimicrobial resistance. RESULTS: (1) The frequency of methicillin-resistant Staphylococcus aureus (MRSA) were different between Beijing and Hubei regions; (2) Most of Staphylococcus aureus were isolated from wound and respiratory tract secretions; of Staphylococcus aureus isolates from respiratory tract secretions, the frequency of MRSA was 59.2%(161/ 272) and 39.9%( 105/263) in Beijing and Hubei, respectively; (3) The results also revealed that the major multiresistant profiles of MRSA were (chloramphenicol, ciprofloxacin, enythromycin, gertamicin, sulfamethoxazole,CCpEGSt) (20.6%) and CCpESt (9.1 %) in Hubei province, and CCpEG (14.4%)and CCpEGSt (8.4%)in Beijing city; (4) The isolates of methicillin-sensitive Staphylococcus aureus (MSSA) from Beijing were susceptible to most of antimicrobial agents routinely used in clinic including chloramphenicol, gentamicin, ciprofloxacin and sulfamethoxazole/ trimethoprim, and same results were found in Hubei except for sulfamethoxazole/ trimethoprim. CONCLUSIONS: Multiresistant phenotypes of MRSA were different,and also antimicrobial resistance of MRSA and MSSA was some differences between Beijing and Hubei regions.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2002年第3期185-187,210,共4页
The Chinese Journal of Clinical Pharmacology
