原发性高血压血栓前状态标志物变化及其意义

The Markers of prothrombotic state in patients with essential hypertension

目的 :探讨血栓前状态 (PTS)在原发性高血压 (EH)患者的作用和意义。方法 :使用酶联免疫吸附法和凝固法测量 5 9例EH患者 (EH组 )和 2 0例正常者 (对照组 )外周血浆因子Ⅷ相关抗原 (vWFAg)、血小板a颗粒膜蛋白 14 0 (GMP 14 0 )、D 二聚体 (D dimer)和纤维蛋白原 (Fg)的水平变化。并对不同分级或分层的EH患者的上述指标进行比较。结果 :与对照组相比 ,EH组血浆vWFAg、GMP 14 0、D dimer、Fg水平均显著升高 (P <0 .0 5 )。 2、3级高血压或中危、高危、极高危EH患者上述指标与正常者、1级或低危EH患者相比均显著升高 (P<0 .0 5 ,<0 .0 1) ,而 1级或低危EH患者与正常者相比上述指标无显著意义的升高 (P >0 .0 5 )。结论 :EH患者存在PTS 。

Objective:To assess the markers of prothrombotic state in patients with essential hypertension(EH).Method: Levels of von willebrand factor antigen(vWFAg)、platelet alpha granule membrane protein 140(GMP 140), fibrin D dimer(D dimer)and fibrinogen(Fg) were measured by ELISA in 59 patients with ET and 20 normal controls. All parmeters were compared in the EH patients with different class and stratification.Result: To be compared with control, EH patients had higher plasma levels of vWFAg、GMP 140、D dimer and Fg(P< 0.05 ). These parameter in patients with class 2、3 or risk、higher risk and very high risk group were significantly increased compared with control group and patients with class 1 or low risk group (P< 0.05 、P< 0.01 ). There were no significant difference between the patients with control group and class 1 or low risk group(P> 0.05 ).Conclusion: There is increased markers of prothrombotic state in class 2, 3 hypertension, it is related to the level of blood pressure and risk factors.