氨氯地平对稳定型劳力性心绞痛的疗效观察

Effect of Amloclipine in patients with stable exertional angina

目的 :观察氨氯地平与传统药物相结合对稳定型劳力性心绞痛患者的疗效及耐受性。方法 :在 1周的时间内经 2次运动试验 ,结果为阳性且运动持续时间变异低于 10 %的 5 4例稳定型劳力性心绞痛患者入选 ,每天给予单一的 β 受体阻滞剂或长效硝酸酯类治疗的同时给予氨氯地平 5mg ,每日 1次 ,连用 8周。 结果 :治疗后与治疗前相比 ,运动耐量和总工作量显著提高 (P <0 .0 1) ,至心绞痛发作时间及ST段下降 1mm的时间均明显延长 (P <0 .0 1) ,其中有 18例患者 (33.34% )试验后不再有ST段下降 1mm ,而对心率 血压乘积的影响差异无显著性意义 (P >0 .0 5 )。氨氯地平应用 8周后 ,患者心绞痛发作次数显著减少且硝酸甘油消耗量明显降低。治疗 8周内 ,出现不良反应 5例 (9.2 5 % ) ,但症状轻 ,无需停药。治疗前后血生化及肝肾功能无改变。结论 :氨氯地平 5mg每天 1次与其他药物联合应用对稳定型劳力性心绞痛患者能增加运动耐量 ,且安全有效 。

Objective:To assess the effects of amloclipine in patients with stable exertional angina.Method: The study included 54 stable exertional angina patients with two positive exercise tests within one week, and the difference of duration of exercise between two tests ≤10%. Amloclipine was combined with the β blockers or long acting nitrates. The total time for treatment was 8 weeks. Result: The results showed that amloclipine significantly increased total work load, time to onset of angina and time to 1 mm ST segment depression (P< 0.01 ). After treatment,18 patients ( 33.34 %) didn't showed ST depression ≥1 mm during exercise, however, rate pressure product did not change significantly (P> 0.05 ). Amloclipine reduced the number of anginal attacks and the mean nitrate consumption per week. During the period of amloclipine therapy, there were 5 cases with adverse effects reported( 9.25 %), but their symptoms were mild and it was unnecessary to withdraw the drug. Conclusion: For patients with stable exertional angina, Amloclipine increases the exercise capacity. The drug is safe and effective and well tolerated by patients.