北京、库尔勒地区胃食管反流病与幽门螺杆菌感染的临床观察

Clinical observation on gastro-esophageal reflux disease and Helicobacter pylori infection in Beijing and Korla,Xinjiang

目的了解北京、新疆库尔勒(南疆)不同地区、性别、民族其成人胃食管反流病(GERD)、反流性食管炎(RE)的检出率及幽门螺杆菌(Hp)感染的情况,以期指导临床治疗。方法2000年7至12月,对北京、库尔勒两地有上消化道症状患者778例,进行胃镜、病理检查及快速尿素酶试验,部分患者还进行了24h食管pH动态监测和13C呼气试验。结果(1)北京地区汉族、库尔勒地区汉族和维族GERD检出率分别为6.4%、13.7%和25.5%(P<0.01);RE检出率分别为3.1%、6.6%和15.7%(P<0.01)。(2)北京地区汉族、库尔勒地区汉族和维族男性GERD检出率分别为6.5%、12.9%和25.0%(P<0.01),RE检出率分别为4.5%、9.7%和25.0%(P<0.01);女性GERD检出率分别为6.4%、14.4%和26.3%(P<0.05),RE检出率分别为1.3%、3.3%和0%(P>0.05)。(3)北京地区汉族、库尔勒地区汉族、维族GERD患者Hp感染率分别为20.0%、24.0%和23.1%(P>0.05);RE患者Hp感染率分别为23.5%、25.0%和25.0%(P>0.05)。结论北京和库尔勒地区不同民族、性别的GERD、RE的检出率均有差异,以后者为高,而其GERD、RE患者的Hp感染率差异无统计学意义。

Objective To study the relationship between the detection rate of gastro-esophageal reflux disease(GERD),reflux esophagitis(RE) and Helicobacter pylori(Hp) infection on adults from different places, sexes,nationalities and living environment in Beijing and Korla, to further find out the clinical features and related factors between GERD and RE occurred in the hinterland and Northwest China. Methods From July to December 2000, 778 cases aged 14 to 86 years old , rural / urban citizens in Beijing and Korla , accepted the electronic gastroscopy examination, HpRUT and the pathology test(Giemsa)to look for Hp infection 13C-UBT was done to find out Hp infection in Beijing Jishuitan Hospital. Those having such typical symptoms as heartburn, chest-ache, acid reflux ,nausea and emesis (the course of the disease excceds 3 weeks and the above symptoms appear at least 3 days a week.) were diagnosed as GERD. The RE was diagnosed under gastroscopy. Ambulatory 24 h esophagus pH monitoring and esophagus pathology were adopted in Beijing Jishuitan Hospital. Results (1)The detection rates of GERD in Hans of Beijing Jishuitan Hospital and Hans and Uygurs of Korla are 6.4%, 13.7% and 25.5% (P< 0.01) and those of RE are 3.1%, 6.6% and 15.7% (P< 0.01) respectively. (2) The detection rates of GERD in Hans of Beijing Jishuitan Hospital, and the Hans and the Uygurs in Korla, are 6.5%, 12.9% and 25.0 %(male)(P< 0.01) and 6.4%, 14.4% and 26.3%(female)(P< 0.05) respectively. (3)The detection rates of GERD with Hp infection in Beijing and Korla are 20.0%, 24.0% and 23.1%(P > 0.05), and those of RE with Hp infection are 23.5%, 25.0% and 25.0%(P >0.05) respectively. Conclusion The detection rates of GERD and RE in Korla were much higher than those in Beijing . The detection rates of GERD and RE in males / females in Korla were higher than those in Beijing. The study shows that there aren't any relationships between Hp infection and GERD / RE for patients in different places, nationalities and living environments.