阿苯达唑脂质体中磷脂含量测定

Visible spectrophotometry analysis of phospholipid in oral liposomal albendazole

目的:建立阿苯达唑脂质体中磷脂含量的测定方法。 方法:利用可见分光光度法测定 ,检测波长 4 85nm。结果 :磷脂在 0 .0 1～ 0 .1mg/ m l浓度范围内呈现良好的线性关系 (r =0 .9993) ,平均回收率为 99.84 %。结论 :本方法灵敏、准确、简便 ,不受阿苯达唑共存的干扰 。

Objective: To establish a method of determining the concentration of phospholipid in oral liposomal albendazole (L ABZ). Method: The concentration of phospholipid in oral liposomal albendazole was determined with visible spectrophotometry, the determination wavelength was 485 nm. Result: The method was linear between phospholipid concentration of 0.01~0.1 mg/ml, the standard regessive curve was C(mg/ml)=0.412 0 A-0.002 8, r=0.999 3. The average recovery rate was 99.84%. Conclusion: The results showed that this method could eliminate the interference of albendazole. The method is simple, rapid and accurate.