应用生长抑素及抑肽酶制剂治疗急性胰腺炎疗效观察

Clinical Observations on the Curative Effect of Somatostatin and Protease Inhibitor in the Treatment of Acute Pancreatitis

目的 :分析生长抑素类似物、抑肽酶治疗急性水肿性胰腺炎的临床疗效。方法 :随机抽取 4 4例急性水肿性胰腺炎患者 ,按治疗方法分为 3组 ,16例应用生长抑素类似物 ,12例应用抑肽酶 ,16例一般治疗 ,统计住院天数、住院费用、血淀粉酶恢复正常时间、腹痛缓解时间 ,评价 3组治疗效果。结果 :生长抑素组与抑肽酶组相比有近似的治疗效果 ,但住院费用较高 ;普通组血淀粉酶恢复正常时间和腹痛缓解时间均较长。 3组住院时间近似。结论 :应用生长抑素或抑肽酶制剂对缓解症状有较好的效果 ,但生长抑素治疗急性胰腺炎费用较高 。

Objective: To evaluate the clinical curative effect of somatostatin and gabexate mesilate in the treatment of acute edematous pancreatitis. Methods: We performed a retrospective analysis to 44 patients with acute edematous pancreatitis from 1998～1999.16 cases (group A)were given somatostatin ,12 cases(group B)were given gabexate mesilate and 16cases(group C)were given only general drugs. We observed the hospitalization day ,the hospitalization fee ,the recurrent time of amylase in serum and the improvement time of abdominal pain. Results: The hospitalization day were the same in three groups .Group A costed much more than group B and C, and group C had a long recurrent time of seroenzyme and a long improvement time of abdominal pain. Conclusion: We should choose the suitable way according to the condition of different cases in the treatment of acute pancreatitis.