消化性溃疡患者CagA-Hp感染与血清IL-8、IL-10的相关性研究

Correlative Study between Helicobacter Pylori CagA Infection and Serum Levels of IL-8 and IL-10 in Peptic Ulcer

目的 :探讨消化性溃疡 (PU)患者伴有CagA -Hp感染与其血清IL - 8、IL - 10之间的关系。方法 :取H .pylori阳性PU患者 10 0例 ,其中CagA -Hp抗体阳性患者 5 0例 ,CagA -Hp抗体阴性患者 5 0例 ,采用ELISA法分别测定其血清IL - 8和IL- 10水平。结果 :消化性溃疡患者中CagA -Hp抗体阳性组血清IL - 8和IL - 10显著高于CagA -Hp抗体阴性组。CagA -HpIgG抗体阳性患者中 ,胃溃疡与十二指肠球溃疡患者血清中IL - 8和IL - 10水平比较无显著性差异。结论 :消化性溃疡患者感染CagA -Hp阳性与血清IL - 8和IL - 10升高有关 ,但IL - 8和IL - 10水平与溃疡发生的部位无关。

Objective: To study the relationship between serum levels of IL-8 and IL-10 and peptic ulcer patients with Cag A + Helicobacter pylori infection.Methods:100 patients with Hp positive peptic ulcer were devided into two groups according to Helicobacter pylori CagA + or CagA -. We used ELISA methods to measure the serun levels of IL-8 and IL-10 in peptic ulcer patients. Results: Serum levels of IL-8 and IL-10 in CagA + group was significantly higher than in CagA - group, There was no significant difference between duodenal ulcer and gastric ulcer in CagA + group. Conclusion:CagA + H.pylori infection is associated with increased IL-8 and IL-10 in peptic ulcer patients. The increasion of IL-8 and IL-10 levels is not related with the location of peptic ulcer.