复方苦参注射液治疗银屑病的实验研究

Study on therapeutic effect of compound radix sophorae flavescentis injection

目的 :研究复方苦参注射液对银悄病的两种动物实验模型的作用。方法 :采用小鼠阴道上皮细胞有丝分裂模型及小鼠尾部鳞片表皮模型 ,以甲氨碟呤为阳性对照 ,评价复方苦参注射液抑制细胞有丝分裂和促进颗粒层形成的作用。结果 :复方苦参注射液能非常显著地抑制小鼠阴道上皮细胞有丝分裂 (P <0 .0 1) ,并能非常显著地促进小鼠尾部鳞片表皮的颗粒层形成(P <0 .0 1) ,而且两种作用均较甲氨碟呤为强。结论 :复方苦参注射液对小鼠银屑病模型具有较好的药理作用 ,其治疗银屑病的机理可能与抑制表皮细胞增生过快和促进表皮形成颗粒层有关。

OBJECTIVE:To study the therapeutie effects of compound radix sophorae flavescentis injection in two animal models. METHOD:The authors used two kinds of animal experimental models, mouse vaginal epitheliun in estrus cycle and mouse tail scaled epidermis to assess the effect of compound radix sophorae flavescentis injection on epithelial mitosis and epidermal keratinization respectively. The positive contrast was Methotrexate. RESULTS:Compound radix sophorae flavescentis injection can inhibit the mitosis in mouse vaginal epithelium ( P <0.01) and promote the formation of granular layer on scale epidermis of mouse tail ( P <0.01) significantly. CONCLUSION:Compound radix sophorae flavescentis injection had a good therapeutic effect for psoriatic mouse models. The mechanism is related to the inhibition of hyperplasia of epidermis cells and the promotion to the formation of granular layer.