咳停片祛痰作用及析方研究

Expectorant effect of Keting tablets and analysis of the prescription

目的 :观察咳停片的祛痰作用 ,通过初步析方评价该处方的配伍合理性。方法 :分复方组 (咳停片 )、无氯组 (不含氯化铵的咳停片 )和氯化铵组 3组 ,比较 3组对小鼠气管酚红排泌和青蛙食道纤毛运动的影响。结果 :复方组、无氯组、氯化铵组均能增强小鼠气管酚红排泌量 ,加快青蛙食道纤毛运动的速度 ,但复方组的作用强度明显优于无氯组或氯化铵组。结论 :氯化铵与中药成分的协同作用证明咳停片是一个合理的处方。

OBJECTIVE:To study expectorant effect of Keting tablet (KT) and evaluate the prescription reasonableness by exploring pharmacodynamics of its components. METHOD:The prescription was divided into three groups, i.e. as compound prescription (KT), non ammonium chloride (including all the components of KT but ammonium chloride) and ammonium chloride. Their different expectorant effects on the tracheal phenol red secretion in mice and the esophageal mucociliary transport in frog were observed.RESULTS:All groups increase tracheal phenol red secretion and mucociliary transport, but the effect of KT was more potent than non ammonium chloride or ammonium chloride.CONCLUSION:Synergism between ammonium chloride and the Chinese medicine of KT demonstrated KT is a reasonable prescription.