全叶马兰的抗炎镇痛作用研究

Analgesic and anti-inflammatory effects of Quanyemalan

目的 :探讨全叶马兰的抗炎镇痛作用。方法 :用大白鼠足趾肿胀法和小白鼠耳廓肿胀法观察其抗炎作用 ;用大白鼠钾离子皮下透入致痛法和小白鼠扭体法 ,观察全叶马兰的镇痛作用。结果 :全叶马兰能对抗新鲜鸡蛋清和二甲苯的致炎作用 ,并能加强哌替啶的镇痛作用 ,与生理盐水对照组比较差异非常显著 (P <0 .0 1)。结论 :全叶马兰有明显的抗炎镇痛作用。

OBJECTIVE:To study the analgesic and anti inflammatory effects of Quanyemalan. METHOD:The anti inflammatory effects was determined with the model of the swelling of mouse ear and the rat carrageenin paw edema. The analgesic effect was edtermined with, mouse writhing method and rat subcutaneous K + penetrate mothod. RESULTS:Compared with NS control group, Quanyemalan could reduce the swelling degree of mouse ear and rat paw edema, and could also strengthen the analgesic effect of pethidine ( P <0.01). CONCLUSION:Quanyemalan has prominent analgesic and anti inflammatory effects.