应用不同催化剂合成邻氨基苯甲腈的研究

Study on the synthesis of o-amino benzonitrile using different catalysis

目的 :研究邻氨基苯甲腈的合成方法。方法 :采用醇碱、路易斯酸及金属氧化物等为催化剂 ,以靛红 3 肟为原料合成邻氨基苯甲腈。结果 :合成的产率为 71.2 % ,结构经熔点确证。结论 :碱性催化剂优于路易斯酸性催化剂 ,金属氧化物催化适合于工业化生产。

OBJECTIVE:To study the synthesis of o amino benzonitrile.METHOD:Using basic, lewis acid and metal oxide as catalysis, o amino benzonitrile was synthesized from Isatin.RESULTS:The total yield of o amino benzonitrile was 71.2%. The final product was identified by melting point.CONCLUSION:Basic catalysis is superior to Lewis acid catalysis. Using metal oxide is suitable for industrialization.