5-氨基-2,4,6-三碘异酞酸的合成

Study of Synthesizing 5-Amino-2,4,6-Triiodoisophthalic Acid

目的 :合成非离子含碘造影剂的中间体 5 -氨基 - 2 ,4,6 -三碘异酞酸。方法 :以间苯二酸为原料 ,经硝化、还原与碘化 ,合成 5 -氨基 - 2 ,4,6 -三碘异酞酸。结果 :每步均经改进 ,总收率达 5 0 .2 % ,所得产品熔点、IR、1HNMR、13CNMR光谱数据 ,与文献报道一致。结论 :本工艺路线方法简单 ,原料易得 ,易工业化生产。

OBJECTIVE:To synthesize 5 amino 2,4,6 triiodoisophthalic acid, the intermedia of nonionic iodinated X ray contrast agents. METHOD:With the isopthalic as the starting material, 5 Amino 2,4,6 triiodoisophthalic acid was synthesized from isophthalic acid by a three step procedure, nitration, reduction and iodination.RESULTS:Each step was modified and improved. The overall yeilds was 50.2%. The melting point and IR? 1HNMR? 13 CNMR of the product prepared were identical to that of the reported one.CONCLUSION:The process can be easily controlled and is suitable for a scale production.