肺栓塞患者血液中循环内皮细胞的变化

Circulating Endothelial Cell in Pulmonary Embolism

目的 :观察肺栓塞患者血液中循环内皮细胞 (CEC)的变化。方法 :全部研究对象 65例 ,对照组 3 2例 ,肺栓塞组 3 3例。按改良的Hladovec法测定血液中CEC ,在显微镜下观察并计数。结果 :肺栓塞组CEC明显高于对照组 ,有极显著性差异 (P <0 0 1)。CEC数值与性别无明显相关 (P >0 0 5 )。CEC与血浆中同型半胱氨酸水平及动脉血氧分压有明显相关 (γ =0 45 6γ =0 117,P均 <0 0 5 )。结论 :肺栓塞患者血中CEC明显高于正常水平。CEC的变化与动脉血氧分压及血浆同型半胱氨酸水平相关。

Objective:To observe the alteration in circulating endothelial cell (CEC) in patients with pulmonary embolism. Methods:The subjects were divided into two groups:the patient group ( n =33) and the control group ( n =32).We used the modified Hladovec method to check endothelial cells,and to count the CEC under the microscope. Results:The CEC count in the patient group was higher than that in the control group.The increase in CEC count in the patient group was related to the higher homocystine (HCY) and the lower PaO 2,but it was not related to sex. Conclusion:The CEC count is significant increased in the patient group.The rise in CEC count may be related to the hiher Hcy and the lower PaO 2.