慢性阻塞性肺疾病患者血浆可溶性细胞间粘附分子-1含量变化的研究

Study on the Change of Soluble Intercellular Adhesion Molecule-1 in Plasma in Chronic Obstructive Pulmonary Disease

目的 探讨可溶性细胞间粘附分子 1 (sICAM 1 )在慢性阻塞性肺疾病 (COPD)中的作用。方法 COPD患者 35例 ,分为缓解期组 1 5例 ,加重期组 2 0例 ;健康体检者 1 8例作正常对照组。用ELISA法测定各组血浆中sICAM 1的含量 ,肺功能仪测量 1s用力呼气容积占用力肺活量的百分比 (FEV1 /FVC) ,并将两者作统计学相关分析。结果 正常对照组、COPD缓解期组和加重期组的血浆sICAM 1含量分别为 (2 1 .40± 3 .596) μg/L、(30 .59± 4 .1 55)μg/L和 (38.40± 3 .943) μg/L ,3组组间差异均有统计学意义 (P <0 .0 1 ) ;FEV1 /FVC分别为 (97.4± 8.0 5) %、(53 .3±7.85) %和 (48.7± 3 .72 ) % ,3组组间差异亦有统计学意义 (P <0 .0 5) ;COPD缓解期组血浆sICAM 1与FEV1 /FVC呈负相关 (r =- 0 .738,P <0 .0 0 2 ) ,加重期组亦存在负相关关系 (r =- 0 .864 ,P <0 .0 0 1 )。结论 ICAM 1参与COPD的发病过程 ,血浆sICAM

Objective To investigate the role that soluble intercellular adhesion molecule 1(sICAM 1) in chronic obstructive pulmonary disease(COPD).Methods The plasma from 15 patients with stable COPD,20 patients with exacerbated COPD and 18 normal controls were all tested for sICAM 1 by an indirect ELISA.Correlations are done between sICAM 1 in plasma and the levels of FEV 1/FVC.Results The levels of sICAM 1 in normal group,the stable COPD group, and the exacerbated COPD,group are 21.40±3.596 μg/L, 30.59±4.155 μg/L and 38.40±3.943 μg/L respectively.There are statistical differences among the three groups (P<0.01).The levels of FEV 1/FVC in three groups are 97.4±8.05%,53.3±7.85% ,and 48.7±3.72% the respectively.There are also statistical differences among the three groups (P<0.05).There are negative correlations between sICAM 1 in plasma and FEV 1/FVC in the stable COPD group (r=-0.738,P<0.002) and the exacerbated COPD group (r=-0.864 P<0.001).Conclusion ICAM 1 has close relationship with the pathogenesis of COPD.The level of sICAM 1 in plasma may be useful as a marker of disease activity, severity and prognosis in COPD.