补充牛磺酸对高胆固醇血症大鼠脂代谢的影响

Effect of Taurine on Lipid Metabolism in Hypercholesterlomic Rats

目的 研究不同剂量水平的牛磺酸对高胆固醇血症大鼠脂质代谢的影响。方法 将断乳SD大鼠 4 0只 ,经高脂饲料诱导成高胆固醇血症模型后 ,按体重和血浆总胆固醇均衡的原则分为 5组 ,以高脂饲料和正常饲料为对照组 ,其余 3组分别在高脂饲料的基础上添加不同水平 (0 6 %、1 35 %、3% )的牛磺酸 ,观察牛磺酸对大鼠脂质代谢的影响 ,实验持续 5周。结果 与高脂对照组相比 ,不同剂量水平的牛磺酸均可显著影响大鼠血浆脂质水平 ,降低AI;0 6 %剂量水平的牛磺酸可显著升高大鼠血浆HDL -C、Apo -Al,降低血浆Apo-B水平 ;1 35 %和 3%剂量的牛磺酸对降低血浆TC、LDL -C、TG及肝脏TC ,升高HDL -C/LDL -C的比值 ,促进粪胆汁酸排泄效果较好 ,其中 3%剂量水平的牛磺酸效果最明显。

Objective This study investigated the effect of taurine on serum and liver cholesterol levels,and its mechanism in hypercholesterolemic rats.Methods Female weanling SD strain rats(80～100g),were divided into five groups,eight rats per group.As the control groups,Group A and B were fed either the high-cholesterol diet or normal diet.Group C?D?and E were given one of the high-cholesterol diets incorporated with taurine at the levels of 0 6%?1 35% or 3% respectively.The experiment lasted five weeks.Results All levels of taurine could significantly lowered the cholesterol levels of rats,but high level of taurine was more profound.0 6% level of taurine significantly increase plasma HDL-C?Apo-AI and lowed plasma Apo-B;1 35% an 3% levels of taurine significantly lowered TC?LDL-C?TG levels in plasma,increased the amount of fecal bile acids and ratio of HDL-C/LDL-C;effection of taurine at 3% level was more better.Conclusion Taurine have good effection on lipid metabolism in hypercholesterlomic rats.