酒精致大鼠生殖系统损伤模型的建立及其检测

Effects of Ethanol on Rats Generation System

目的 研究酒精对大鼠生殖系统的损伤及其对优生的影响。方法 用不同剂量的酒精给大鼠灌胃 ,在分别作用 1～ 2个生精周期后 ,进行大鼠的睾酮、精子数目、精子活力、精子质量及睾丸的组织学检测。结果 高剂量的酒精作用于大鼠 2个生精周期 ,大鼠的睾丸和附睾的相对重量有所下降 ;精子活力和活率降低 (P <0 0 1) ;精子的崎形率升高 (P <0 0 1) ,性激素水平也降低 ,睾丸组织也有明显的形态学变化。结论 长期大量饮酒 ,可以引起生殖系统损伤 ,因此 。

Objective To study the injury of rats sexual system by alcohol and its effect on eugeny.Methods Various doses of alcohol were administered through gastric tube in rats.At the different time alchol had been given,the blood,sperm,and sexual organs of rats were taken to test the change in hormone,sperm quality and histology.Results When the rats had been given alchol with high doses and for a longer time,their relative gravity of testises and epididymis(mg/100g)were decreasd.The rate of sperm activity was much weaker than normal′s( P <0 01).The propertion of living sperms was significantly less than normal′s( P <0 01).The rate of the sperm deformity was higer than the norma′s( P <0 01).The content of LH?FSH and T level in the serum was lower than the normal′s.The histology of the sexual organ also have morphology changes.Conclusion Alcohol can cause sexual system injury and so,reducing alchol intaking is important too eugeny.