单亲亲子鉴定的分析研究

Analysis of duo paternity testing

目的从理论和实际应用方面客观评价13～15个STR位点应用于单亲亲子鉴定的准确性。方法依据中国人群基因频率资料,计算单亲亲子鉴定的非父排除率及单亲亲子鉴定的亲子关系概率,并选择有明确排除结论的104例排除案例,分析统计其中父-子二联体出现的排除指标数。结果对于单亲亲子鉴定,选用13～15个STR位点,联合非父排除率为0.9805～0.9906;亲子关系概率均大于99.73%。104例二联体排除案例中,有3例的排除指标数小于2,未发现排除指标为零的现象。结论若应用ProfilerPlus和CofilerPlus试剂盒的13个STR位点进行日常单亲亲子鉴定工作,存在微弱漏判非父的风险,必要时增加检测指标数。不排除案例的单亲亲子鉴定,其亲子概率均可达国际认定标准。

Objective The study was carried out on application of13to15STR loci in duo paternity test.Methods The value of PE and CPE were caculated depending on the gene frequency of those STR loci in chinese population.The STR loci imcopatibilities were analyzed in104cases of paternity exclusion.Results CPE of13to15STR loci could reach0.9805to0.9906.the RCP was over99.73%.In104cases of paternity exclusion,less than2loci imcompetibilites were only found in two cases.Conclusion There was a low risky of false paternity inclusion in duo paternity test by using of13STR loci.If neces sary,the genetic markers should be added.The RCP of those cases without imcompatibilities could all reach paternity inclusion stardand.