糖尿病患者治疗前后锌铜代谢平衡的研究

THE METABOLIC BALANCE OF ZINC AND COPPER IN DIABETES MELLITUS

糖尿病患者在治疗前锌代谢呈负平衡,铜代谢呈明显的正平衡,治疗后锌铜代谢趋于正常。单相关分析发现,锌铜代谢紊乱与血糖明显相关,多因素逐步回归分析发现,锌负平衡的主要影响因素是肠锌吸收障碍和尿锌排泄增加。

Zinc(Zn) and copper(Cu) balance tests were conducted in patients with diabetes mellitus. The results revealed that the negative balance of Zn and excessive positive balance of Cu were much improved after the management of diabetes mellitus. In addition, a close relationship was found between serum glucose concentration and the disorder of Zn and Cu balance, i.e. serum Zn level, apparent intestinal absorption rate and balance status of Zn were reversely related to serum glucose concentration, whereas urinary Zn, serum Cu level and apparent intestinal absorption of Cu were positively correlated to serum glucose concentration. Poly-factor analysis suggested that hyperzincuria and malabsorption of Zn were the main factors concerning negative Zn balance.