烧伤后维生素E的变化及其与脂质过氧化作用的关系

CHANGES IN VITAMIN E AND ITS RELATIONSHIP TO LIPID PEROXIDATION AFTER BURNS

成年大鼠在体表面积15％Ⅲ度烧伤后,血清维生素E含量自烧伤后1.5小时至7天一直降低,以后逐渐回升,血清、肺组织中脂质过氧化物含量明显升高,3天后下降。血清超氧化物歧化酶和全血谷胱甘肽过氧化物酶活性均下降,前者在14天内不能恢复,后者在烧伤7天后逐渐恢复。烧伤大鼠经腹腔注射维生素E(20mg/100g体重),能明显抑制脂质过氧化物升高,血清、肺的抑制率分别为28％和31％。电镜观察:维生素E组大鼠肺组织未见损害改变,而对照组损害明显。结果表明:烧伤后及早补充维生素E是必要而有效的。

The values of vitamin E in serum were decreased significantly in rats with 15% BSA III burn from 1.5 hours to 7 days postburn, and then restored gradually, while the levels of lipid peroxides in serum and lung were increased from 1.5 hours to 3 days. The activities of superoxide dismutase and glutathine peroxidase in blood were also decreased after burns, the former remaining low within 14 days and the latter restoring after 7 days postburn. After intraperitoneal injection of vitamin E to the burned rats, the overproduction of lipid peroxides in serum and lung was inhibited with inhibition rates of 28% and 31%, respectively. No more pathological changes of ultrastructural picture were observed in lung of the burned rats supplemented with vitamin E as compared to the control. The results showed that it was beneficial to supply vitamin E in treatment of burns as soon as possible.