必需脂肪酸对大鼠实验性缺锌的影响

INFLUENCE OF ESSENTIAL FATTY ACID ON EXPERIMENTAL ZINC DEFICIENCY IN RATS

以饱和脂肪(椰子油)配制缺锌(1.4～1.5ppm)饲料,从第二周起即有死亡,三周时死亡达55％。存活动物有严重缺锌症状。给存活鼠以含锌水(100ppm),症状很快消失,体重增长迅速。以红花油替代椰子油,动物到第四周时仍无缺锌表现,血锌、毛锌与正常近似。调正脂肪酸组成,使亚油酸约占总脂肪酸的20％,实验鼠可在两周后出现缺锌症状,血锌、毛锌低于正常,无死亡。动物可以供作缺锌实验用。

Low zinc (1.4-1.5 ppm) ration containing saturated fat (coconut oil) was fed to weanling rats, death occurred since second week. In third week, total death was 55%. The survivors manifested severe Zn-deficiency symptoms. When they were given Zn supplement in drinking water (100 ppm Zn), the deficient symptoms disappeared quickly and body weights increased rapidly. When coconut oil was replaced by safflower oil, the rats didn't show any Zn-deficiency symptom in 4 weeks. There was no difference in Zn contents of plasma and hair between Zn-deficient rats and the normals. Adjusting fatty acids composition of dietary fat to contain linoleic acid at 20% of total fatty acids, the rats manifested Zn-deficient symptoms after 2 weeks, and Zn contents of plasma and hair were significantly lower than that of normal rats(P<0.001) but no death occurred. The rats can be used for Zn-deficiency experiments.