应激过程中骨骼肌内热休克蛋白(HSPs)的变化及其调控机制

Changes of Heat Shock Proteins in Skeletal Muscle During Stress and Its Molecular Mechanism Controlling

在应激反应时,细胞可快速产生一系列蛋白质,这些蛋白质即被称为热休克蛋白(HSP)。人们认为HSPs是一种分子伴侣,在保持细胞稳态当中起着十分广泛的作用。骨骼肌中所表达的HSPs包括小分子HSP家族(泛素、alpha B-晶体蛋白、HSP20、HSP27),HSP70、HSP60、HSP90等。骨骼肌是一个非常复杂的系统,其中的收缩蛋白是由各种不同的肌肉纤维类型所组成,每一种肌纤维均具有其各自的生化组成和功能特征。HSPs 的表达与肌纤维的类型有关。在肌病或体育锻炼过程中HSPs有明显的变化,然而HSP的诱导及调控的分子机制以及它在维持肌肉功能方面的作用尚未完全明了。本文主要阐述了骨骼肌中HSP的变化及其调控的分子生物学机制。

In the process of stress, cells rapidly produce a series of new proteins known as heat shock proteins (HSP). HSPs are considered to be molecular chaperones which play a universal role in maintaining cellular homeostasis. It is known that different HSPs are expressed in skeletal muscle, namely, small HSPs, HSP70, HSP60 and HSP90. It seems that the induction of HSPs differs with muscle fiber type suggesting HSP expression is muscle fiber type specific. HSPs have been shown to respond in muscle diseases and following exercise. However, the molecular mechanisms of HSP induction and regulation are not completely understood. This review discusses the changes of HSPs in skeletal muscle and its molecular mechanism controlling.