非离子表面活性剂囊泡包封药物头孢唑啉钠的研究

Initial Study of Non-ion Surfactant Niosomes as Drug Carriers

实验通过超声波法制备了吐温类非离子表面活性剂囊泡 ,研究了它们对药物头孢唑啉钠(CEZ)的包封作用以及被包封的CEZ在模拟胃液及模拟肠液中的释放情况。实验表明 ,吐温 40与胆固醇体积比为 1∶1时形成的非离子表面活性剂囊泡对 1mg mL的CEZ的包封率是 2 0 % ,而且在模拟胃液和模拟肠液中 ,对包封的药物都有一定的缓释作用 。

Niosomes are prepared with non ion surfactant by ultrasonication. The report describes the entrapment efficiency of CEZ encapsulated into noiosomes and release profiles in simulated gastric and intestinal fluid. The results show that the entrapment efficiency of niosomes prepared by Tween40 with Cholesterol ( φ Tween40 =50%)reached 20% for Cefazolin Sodium (CEZ).In simulated gastric and intestinal fluid, the release rate of CEZ entrapped in niosomes is slower than that of free CEZ solution. Therefore non ion surfactant niosomes might be a potential dosage form. The release profiles in simulated gastric and intestinal fluid showed a controlled release tendency to some extent.