nm23-H1表达产物在恶性黑素瘤中的表达

Expression of nm23-H1 in malignant melanoma

目的 研究 nm2 3- H1蛋白产物在恶性黑色素瘤的表达特点及其与转移的关系。方法 应用免疫组化 S- P法检测 5 1例恶性黑色素瘤和 32例黑色素细胞痣中 nm2 3- H1蛋白产物。结果 nm2 3- H1蛋白的阳性表达率在恶性黑素瘤和黑色素细胞痣分别为 39.2 %和 2 1 .1 % ,差别无显著性 ( P >0 .0 5 ) ,恶性黑素瘤转移组明显低于无转移组 ( P <0 .0 5 )。结论 nm2 3- H1基因表达在抑制恶性黑色素瘤转移过程中起一定作用 ,检测 nm2 3-

Objective To study the expression of nm23 H1 and its correlation with metastasis in malignant melanoma Methods The expression of nm23 H1 protein in 51 cases malignant melanoma and 32 cases nevocellular nevus was studied by S P immunohistochemical technique Results The positive expression rate of nm23 H1 protein in malignant melanoma and nevcellular nevus were 39 2% and 21 1%,respectively.The difference of nm23 H1 protein expression between patients with and without metastasis was statistically significant (P<0 05) Conclusions The expression of nm23 H1 gene may play important role in inhibting metastasis of malignant melanoma and serve as a factor of metastasis