地塞米松对腹腔海水浸泡伤的保护作用

Protective effect of dexamethasone on celiac seawater immersion wound in rats

目的 :观察早期应用地塞米松 (DXM)对腹腔海水浸泡伤大鼠的救治效果。方法 :将 88只腹腔海水浸泡伤 SD大鼠随机均分为模型组和地塞米松治疗组 ,观察术后不同时间 (n=6 )丙氨酸转氨酶 (AL T)、血清淀粉酶 (AMS)、尿素氮 (BUN)、肌酸激酶 (CK)、丙二醛 (MDA )、超氧化物歧化酶 (SOD)及乳酸 (L A )水平变化 ;同时计算两种不同处理情况下实验动物的存活情况。结果 :地塞米松治疗组术后 12、2 4和 36小时存活率分别为6 0 %、35 %和 2 0 % ,而模型组分别为 35 %、2 5 %和 10 %。治疗组 SOD水平显著高于模型组 (P均 <0 .0 5 ) ,而AL T、AMS、BU N、CK、MDA及 L A水平均显著低于对照组 (P<0 .0 5或 P<0 .0 1)。结论 :腹腔海水浸泡后早期应用 DXM能保护机体多器官功能 。

Objective:To explore the protective effects of dexamethasone(DXM) on celiac seawater immersion wound.Methods:Eightyeight SD celiac seawater immersion rats were randomly divided into model group( n =44) and DXM treatment group( n =44).Postoperative levels of plasma alanine aminotransferase(ALT),amylase(AMS),blood nitric oxide(BUN),creatinine(CK),malondialdehyde(MDA),superoxide dismutase(SOD) and lactic acid(LA) were observed respectively at different time ( n= 6).And survival rate of wounded rats was calculated under conditions of treatment or not.Results:Postoperative survival rates were 60%,35% and 20% respectively in DXM treatment group and 35%,25% and 10% in model group at the time of 12,24 and 36 hours after operation.SOD levels were higher in DXM treatment group than those in model group (both P <0 05).However,levels of ALT,BUN,AMS,CK MDA and LA in DXM treatment group were lower than those in model group respectively( P <0 05 or P <0 01) Conclusions:Early treatment with DXM can protect function of multiful organs,and increase survival rate in rats with open celiac seawater immersion wound