慢性肺心病急性加重期D-二聚体测定的意义

Clinical significance of D-dimmer in exaggerate stage of chronic pulmonary heart disease

目的 :研究应用肝素治疗慢性肺心病患者急性加重期前后血浆D -二聚体含量的变化。方法 :采用酶联免疫吸附法测定 36例慢性肺心病急性加重期患者应用肝素治疗前后以及 30例正常对照组的血浆D -二聚体 ,并进行比较。结果 :慢性肺心病急性加重期的D -二聚体含量明显高于对照组 ,有高度显著差异 (P <0 0 0 1) ,与肝素治疗后患者比较P <0 0 0 1。结论 :血浆D -二聚体含量的测定可以作为慢性肺心病急性加重期肺小动脉血检形成以及应用肝素溶栓的治疗监测。

Objective: It is to study the change of plasma D dimmer in pulmonary heart disease patients with heparin treatment. Methods: Plasma D dimmer of 35' patients with enzyme linked immune sorbent assay (ELISA) before and after heparin treatment and 30 persons in normal control group were measured. Results: The D dimmer contents of patients with pulmonary heart disease at the acute exaggerated stage were significantly higher than that of control group (P<0.001) and heparin treatment group (P<0.001). Conclusion: D dimmer in plasma can be used as an index of the thrombus in small pulmonary artery of chronic pulmonary heart disease and also as an indication for thromboclasis with heparin.