血管紧张素转换酶基因多态性与2型糖尿病合并心脑血管疾病的关系

Relationship Between Angiotensin-converting Enzyme Gene Polymorphism and Cardio-brain Complications in Patients with NIDDM (Type 2 Diabetes Mellitus)

目的 :探讨血管紧张素转换酶 (ACE)基因多态性与 2型糖尿病合并心脑血管疾病的关系。方法 :应用聚合酶链反应 (PCR)技术 ,对 1 74例 2型糖尿病及 6 2名正常对照者的ACE基因插入 /缺失 (I/D)型多态性进行检测。结果 :ACE基因I/D多态性与 2型糖尿病并发冠心病 (心肌梗塞、心绞痛 )、脑梗塞密切相关 ,而对糖尿病伴高血压者无相关关系。糖尿病伴高血压、冠心病、脑梗塞ACED/D型者血浆肾素活性、血管紧张素Ⅱ明显高于对照组 (p <0 0 1 ) ,而醛固酮、血管内皮素无显著差异。结论 :ACEI/D多态性检测对糖尿病合并心脑血管疾病的一级预防有一定的指导意义 ,并有助于冠心病。

Objective To investigate the relationship between angiotensin-converting enzyme gene polymorphism and cardio-brain complications in patients with NIDDM. Methods The angiotensin-converting enzyme (ACE) gene insertion/deletion polymorphism in 174 patients with NIDDM and 62 controls were examined with PCR. Results ACE gene I/D polymorphism was closely related to coronary heart disease ( angina, cardiac infarction) and cerebral infarction in diabetic patients but not with hypertension. Plasma renin activity and plasma angiotensinⅡlevels in complicated diabetic patients with ACE D/D gene were significantly higher than those in the controls ( p <0.01). Their aldosterone and endothelin contents were not significantly different. Conclusion Examination of ACE gene I/D polymorphism was useful for the primary prevention of cardio-brain complications in diabetic patients and helpful in the early diagnosis and therapy of coronary heart disease and cerebral infarction.