毛喉萜的合成研究概况

Review of Forskolin Syntheses

毛喉萜(1),forskolin,具有抗高血压、抗肿瘤转移和抗青光眼等药理活性,以及复杂分子结构所具有的挑战性,引起世界上众多有机合成化学家和药物化学家的研究兴趣。本文主要综述该化合物合成研究的各种策略以及路线设计。同时也简要介绍毛喉萜衍生物的合成及其构效关系。

On account of a number of physiological effects such as antihypertensive,inhibi-ting metastasis of tumor etc.coupled with a substantial structural challenge,forskolin,(1),has emerged as a highly attractive target for synthetic and pharmacological investigations.This paper reviews the strategies in the syntheses of forskolin as well as its derivertives andtheir pharmacological activities.