合成重要中间体-1,4位官能化化合物的简便方法

A Convenient Method for the Preparation of 1,4-Difunctionalized Compounds,an Imporant Intermediate

5,6-取代环烯醚2在乙腈的单重态氧反应有效的生成一系列1,4位官能化化合物3。1,4位官能化化合物为合成上重要的中间体。环烯醚2可以通过β-二酰基化合物1和1,3-二溴丙烷在稀碱(碳酸钾/丙酮)条件下缩合生成。

In acetonitrile,singlet oxygenation of 5,6-disubstituted cyclic vinyl ether 2 yieldsa series of 1,4-difunctionalized compounds 3 in moderate to high yield.Cyclic vinyl ether2 can easily be prepared,by the condensation of β-dicarbonyl compound 1 with 1,3-dibro-mopropane in mildly basic condition(potassium carbonate/acetone).