N-(6-甲基-2-亚甲基吡啶)-(+)-樟脑亚胺体系的不对称烷基化反应

The Asymmetric Alkylations of N-(6-Methyl-2-methylenepyridine)-(+)-camphor Imine System

目前,不对称合成光学活性化合物取得了较大进展,不对称合成α-氨基酸、β-氨基醇、α-取代苄胺的报道很多。但是,不对称合成生物碱类物质——α-取代氨甲基吡啶类化合物还未见文献报道,而此类化合物有潜在的应用前景。为此,我们以(+)

The asymmetric alkylations of the new chiral imine prepared from 2-aminomethyl-6-methylpyridine with(+)-camphor in the presence of lithium diisopropylamine(LDA)arereported,and six different alkylated chiral imine intermediates have been separated and exa-mined,the asymmetric inductions vary between 6%to 67%.According to the CD spectraof the alkylated products,we deduce that the configuration of the main isomeride of thealkylated products is R configuration at C_(11)position by comparing the CD sing pattern of2 e With that of the compound known as R configuration.