某些多氮杂大环的合成与应用

Syntheses and Applications of Some Functionalized Polyazamacrocycles

多氮杂大环与许多金属离子能形成稳定的络合物。由于氮原子是三价的,因而多氮杂大环比冠醚具有更有利的结构;如果再导入羧基、膦酸基以及其他的亲水基团,则可得到一系列能形成水溶性金属络合物的配体。其中某些金属(如铜、钇等)的络合物在人体生理条件下表现出很好的稳定性,结合单原抗体技术的应用,这炎络合物在医疗、诊断方面有实用性。本文简单介绍某些代表性络合物的制备方法、物理性能和可能的应用。

Polyazamacrocycles are known to form stable metal chelate complexes.Owing tothe trivalency of nitrogen atom,functionalization of polyazamacrocycles may be more facilecompared to crownethers.Thus,introduction of carboxylate,phosphonate,or other hydrophilicgroups into the azamacrocycle provides numerous fascinating ligands suitable to form water-soluble metal complexes.Some of them containing even hard ions like lanthanides are verystable in human serum under physiological conditions.They may be useful for therapeutic ordiagnostic purposes.Here we describe briefly preparative aspects,physical properties,andsible applications of some typical functionalized polyazamacrocycles.