2-芳基-5-[4′-(2,2,6,6-四甲基哌啶-1-氧)氨基]-1,3,4-恶二唑自旋标记化合物的合成

Synthesis of 2-Aryl-5-[4'-(2,2,6,6-tetramethyl-piperidine-1-oxyl)amino]-1,3,4-oxadiazoles labeled compounds

2,2,6,6,-四甲基哌啶-1-氧自由基是目前应用最广泛的自旋标记试剂之一,但用哌啶氮氧自由基标记1,3,4-恶二唑类杂环的研究。迄今未见报道。1,3,4-恶二唑杂环衍生物具有抗结核、

Synthesis of elevene new 2-aryl-5-[-4'-2,2,6,6-tetramethyl-piperidine-1-oxyl)am-ino]-1,3,4-oxadiazoles and the characterization of their structures are reported.Preliminaryexperiments in pharmacodynomics showed that the spin labeled compounds possess inhibitaryeffects on B.subtilis,E.coli,P.vulgaris and S.aurreus.