福辛普利和非络地平逆转原发性高血压左室肥厚的对比研究

Comparative study on Fosinoprill and Felodipine converting left ventricular myocardial hypertrophy in essential hypentensive patients

目的 :对比研究福辛普利和非络地平逆转原发性高血压 (EH)左室肥厚的作用。方法 :将 10 4例EH伴左室肥厚的患者随机分为福辛普利组和非络地平组 ,于服药前及服药后 6个月、12个月、2 4个月分别测定左室舒张末内径 (LVDT)、舒张期室间隔厚度 (IVST)、左室后壁厚度 (LVPWT)、左室射血分数 (LVEF)、心排量 (CO)、A峰 /E峰比值 (A/E比值 )。结果 :两组治疗前后比较LVEF、CO均无变化 ,而A/E比值则明显降低 ;左室重量指数 (LVMI)、LVDd、IVST、LVPDWT在福辛普利组明显下降 ,而在非络地平组则无变化。结论 :福辛普利和非络地平均能明显改善左室舒张功能 ,但福辛普利能明显减轻左室肥厚。

Objective To observe the effects of conversal of Fosinoprill and Felodipine on left ventricular myocardial hypertrophy in essential hypertension(EH).Methods 104 EH patients with ventricular myocardial hypertrophy were randomly divided into Fosinoprill group and Felodipine group.Before administration and at 6th month 12th month and 24th month after administration,we measured respectively left ventricular diastolic diameter(LVDd),interventricular septal thick(IVST),left ventricular posterior wall thick(LVPWT),left ventricular ejection fraction(LVEF),cardiac output(CO)and A peak/E peak ratio(A/E ratio).Results Before and after treatment,LVEF and CO of two groups did not change.But A/E ratio of two groups was significantly decreased.Left ventricular mass index(LVMI),LVDd,IVST and LVPWT were decreased remarkably in Fosinoprill group.But they did not change significantly in Felodipine group. Conclusions Fosinoprill and Felodipine may improve left ventricular diastolic function.Only Fosinoprill may significantly reduce left ventricular myocardial hypertrophy.