地高辛与巯甲丙脯酸联合治疗室间隔缺损合并心衰患儿的疗效观察

Effect observation of Digoxin and Captopril on ventricular septal defect complicated with heart failure in children

目的 :评价地高辛和巯甲丙脯酸联合治疗室间隔缺损合并心衰患儿的临床疗效。方法 :3 2例心衰患儿随机分为13例对照组和 19例治疗组。治疗组给地高辛饱和量后维持用药 ,巯甲丙脯酸从小剂量开始递增至每日 0 5～ 1mg/kg ,疗程 3个月。对照组心衰时给以地高辛 ,纠正后即停用 ,随访 6个月。结果 :治疗组心衰控制和罗音消失天数较对照组明显缩短 (t =3 78,P <0 0 1;t =3 5 6,P <0 0 1) ,半年内肺炎反复发作次数减少 (t =4 84,P <0 0 1)。结论 :地高辛和巯甲丙脯酸联合治疗室间隔缺损合并心衰患儿可预防肺炎及心衰发生并缩短其病程。

Objective To evaluate the clinical effect of Digoxin and Captopril on ventricular septal defect combined with heart failure in children.Methods Thirty-two children with heart failure were randomly divided into treatment group(19 cases) and control group(13 cases).The treatment group was given Digoxin saturation dose and maintained the dosage.Captopril was started from small dosage and gradually increased to 0.5-1mg/kg/d for 3 months.Control group was given Digoxin to correct the condition and was followed up for 6 months.Results Heart failure and rales disappeared much more quickly in treatment group than control group(t=3.78,P<0.01,t=3.56,P<0.01).Recurrence times of pneumonia were decreased in 6 months (t=4.85,P<0 01).Conclusions Combination of Digoxin and Captopril to treat ventricular septal defect can prevent pneumonia and heart failure and shorten the period of illness.