可溶性细胞间粘附分子与肝硬化及其并发症的相关性研究

Relationship between soluble intercellular adhesion molecule-1 in liver cirrhosis and its complications

目的 探讨血清可溶性细胞间粘附分子 1(sICAM 1)与肝硬化及其并发症的关系。方法 采用酶联免疫吸附法测定 61例肝硬化患者及 3 4名正常人血清sICAM水平。结果 肝硬化患者血清sICAM 1水平 [(1183 .5 7±491.83 )ng/ml]明显高于非肝硬化患者 [(3 72 .3 8± 182 .49)ng/ml,P <0 .0 1] ,并与血清白蛋白 (ALB)、谷丙转氨酶(ALT)、总胆红素 (TBiL)及肝功能Child分级之间密切相关 (P <0 .0 5 ,P <0 .0 1)。伴门脉高压性胃病 (PHG)肝硬化患者血清sICAM 1水平 [(13 5 3 .14± 497.45 )ng/ml]较无PHG的肝硬化患者 [(110 6.3 1± 3 92 .0 8)ng/ml]及正常对照组显著增高 (P <0 .0 5 ,P <0 .0 1)。

Objective To investigate the relationship between soluble intercellular adhesion molecule 1(sICAM 1) and liver cirrhosis complicated with portal hypertensive gastropathy(PHG). Methods In 61 cases of liver cirrhosis and 34 cases of healthy controls, serum sICAM 1 levels were measured in duplicate by enzyme linked immunosorbent assay using the soluble ICAM 1 Kit.Results Serum sICAM 1 levels in liver cirrhosis were (1183.57±491.83)ng/ml, significantly higher than those of healthy controls (372.38±182.49)ng/ml, P <0.01. They were correlated with the levels of serum albumin and Child's grading of liver function ( P <0.05, P <0.01). Serum sICAM 1 level of liver cirrhosis with PHG was (1353.14±497.45)ng/ml also significantly higher than those without PHG (1106.31±392.08)ng/ml and healthy controls ( P <0.05, P <0.01).Conclusion There is a significant correlation betwee sICAM 1 concentrations in liver cirrhosis with and without PHG, which indicate that sICAM 1 may play a key role in the devlelopment of liver cirrhosis and cirrhosis with PHG.