幽门螺杆菌感染与儿童胃炎关系探讨

Relationship between Helicobacter pylori infection and childhood gastritis

为进一步研究幽门螺杆菌 (Helicobacterpylori,H.pylori)感染与儿童胃炎的关系 ,对我科1998年至2000年间500例3岁～15岁儿童胃镜活检组织进行组织学和H.pylori观察 ,按Sydney胃炎标准对病变分级 ,分析和探讨H.pylori感染与儿童胃炎发展变化的关系。结果表明 :40.4 %的儿童胃炎与H.pylori感染有关 ;而且炎症的程度、淋巴滤泡的形成、嗜酸细胞增多及幽门腺萎缩明显高于无H.pylori感染的儿童胃炎。提示上海地区儿童胃炎有很高的H.pylori感染率 ,H.pylori感染与儿童胃炎关系密切 ,儿童H.pylori胃炎的胃粘膜病理变化比非H.pylori感染者严重。

To explore the relationship between Helicobacter pylori (H.pylori) infection and childhood gastritis,histological examination and H.pylori determination of biopsy specimens collected by gastroscopy were undertaken and gastritis severity was classified with the criteria of Sydney system in 500 children with gastritis at 3 to 15 years old during 1998 to 2000.The results showed that 40.4% of all children with gastritis was correlated with H.pylori infection.The severity of inflammation,the formation of lymphoid follicles,the increase of oxyphil cells and the atrophy of pyloric body of gland were more often observed in children with H.pylori infection comparing to that in children without H.pylori infection.It is suggested that in Shanghai there is a higher incidence of H.pylori infection,which is closely correlated with childhood gastritis.A more severe pathological change of gastric mucosa is noticed in children with H.pylori infection than those in children without H.pylori infection.