硫普罗宁在乳癌化疗中的保肝作用

Protective hepatic role of tiopronin in the patients with breast cancer during chemotherapy.

目的 :观察硫普罗宁 (凯西莱 )在乳癌化疗轻度肝损害患者中的保肝作用。方法 :对56例乳癌选用CMF方案 ,患者随机分为治疗组和对照组。治疗组28例加凯西莱静滴及口服 ,28例患者为对照组用肌苷静滴及口服 ,观察一周期化疗后ALT的变化 ,结果治疗组化疗后ALT值显著低于化疗前组 ,与对照组比较差异有显著性。结论 :对乳癌化疗轻度肝损伤患者凯西莱可对抗化疗性肝损害 ,改善肝脏功能 。

Objective:To observe the protective hepatic role of tiopronin in the patient's of breast cancer with mild hepatic injury during chemotherapy.Methods:In the therapeutic group the chemotherapy and tiopronin were used.the chemotherapy and ATP were used in the control group.The change of ALT was observed for a week after chemotherapy.Results:The level of ALT in the therapeutic group after chemotherapy was obviously lower than that of control group and before chemotherapy(P<0 01).Conclusion:Tiopronin has counteraction chemotherapy on hepatic injury in the patient's of breast cancer with mild hepatic injury during chemotherapy.it may improve hepatic function and ensure the continuity of chemotherapy.