灯盏花素对豚鼠心室肌细胞迟发性外向钾电流的影响

Effect of breviscapine on delayed outward potassium current in single ventricular cell of guinea pig

目的 观察灯盏花素对心室肌细胞迟发性外向钾离子电流的影响。方法 应用全细胞膜片钳制技术。结果 灯盏花素以剂量依赖的方式增加Ik,0 0 1g·L-1灯盏花素使Ik 增大 4 4 6 % (0 0 1<P <0 0 5 ) ,0 0 2 g·L-1灯盏花素使Ik增大 6 0 3% (P <0 0 1) ,灯盏花素此作用经冲洗可部分消退。结论 灯盏花素能促进K+ 通道开放 ,促进K+

AIM To Investigate the effect of breviscapine on delayed outward potassium current in single ventricular cell of guinea pig. METHOD Using whole cell patch clamp technique. RESULTS Breviscapine enhanced I k dose dependently. Breviscapine with the concentration of 0\^01 and 0\^02 mg·L -1 increased I k by 44.6% and 78.3%,respectively. The effect could be reversed by washing. CONCLUSION Breviscapine can open the K + channel and incrase I k .