侧脑室注射3、4二羟基苯甲醛对大鼠心脏血流动力学的作用及其机制

The Effects of Intracerbral-ventricular Injection of Salvia Miltiorrhiza on Cardial Hemodynamics in Rats

目的 探讨 3、4二羟基苯甲醛对大鼠心脏血流动力学作用及机制。方法 以 MP、HR、L VSP、L VEDP、L VP± dp/ dt m ax为指标 ,在氨基甲酸乙酯麻醉的 SD大鼠上观察 3、4二羟基苯甲醛对上述指标的影响。结果 侧脑室注射 3、4二羟基苯甲醛后大鼠 MP、HR、L VSP、L VDEP、L VP± dp/ dt m ax明显减弱 ,10分钟达最低值 ,与生理盐水组和给药前比较差异显著 (P<0 .0 1) ,然后逐渐恢复。侧脑室预先注射 β受体阻断剂心得安可部分阻断 3、4二羟基苯甲醛减弱 MP、HR、L VSP、L VEDP、L VP± dp/ dt m ax的作用。结论 3、4二羟基苯甲醛有明显减弱 MP、HR、L VSP、L VEDP、L VP± dp/ dt max的作用。 3、4二羟基苯甲醛减弱心血管系统的作用可能部分由脑内 β受体介导。

Objective To investigate the effects of Salvia miltiorrhiza (SM) on cardiac hemodynamics in rats and explove the mechanism therein involved.Methods With MP, HR, LVSP, LVEDP and LVP±dp/dt max as the indices, the effects of SM on the SD rats anesthesized with urethane were determined.Results After the injection of SM into the lateral cerebral ventricle of rats, MP, HR, LVSP, LVDEP and LVP±dp/dt max in rats decreased significantly as compared with those of the control group and normal saline group. Conclusion SM has a noticeable effect on the decrease of MP, HR, LVSP, LVEDP and LVP±dp/dt max.The intracerebral-ventricular injection of propranolol in advance can inhibit in part the action of SM on the decrease of MP, HR, LVSP, LVEDP and LVP±dp/dt max, thus suggesting that the inhibitory effect of SM on those indices may be partly mediated by intracerbral β-receptor.