白细胞介素-6在绝经后骨质疏松症发病机制中作用的临床研究

Effect of Interleukin-6 on the Pathogenesis of Postmenopausal Osteoporosis

[目的]探讨白细胞介素-6(IL-6)在绝经后骨质疏松症(PMOP)发病机制中的作用。[方法]根据腰椎骨密度(BMD)扫描结果,将104例受试妇女分为3组,即绝经后骨质疏松组31例、绝经后非骨质疏松组37例、绝经前健康组36例,采用放免法分别测定血清IL-6、雌二醇(F2)和骨钙素(BGP)水平。[结果]绝经后妇女血清IL-6水平高于绝经前妇女,骨质疏松组又高于非骨质疏松组。以非骨质疏松组IL-6为因变量的多元回归分析显示:IL-6与BMD、E2呈负相关关系,与BGP呈正相关关系,与年龄无显著性相关关系。[结论]绝经后骨质疏松症的骨丢失属高转换型,IL-6高表达与骨质疏松症发病以及雌激素减少有关,雌激素水平下降可导致IL-6分泌增多,从而刺激骨吸收,骨吸收超过骨形成导致骨质疏松的发生。

[ Objective] To explore the effect of interleukin-6 (IL - 6) on the pathogenesis of postmenopausal osteoporosis (PMOP). [Methods] According to the result of bone mineral density (BMD) scanning of lumbar vertebrae, 104 women were allocated to three groups. Thirty-one cases of PMOP was assigned to Group A, 37 postmenopausal women without osteoporosis to Group B and 36 healthy premenopausal women to Group C. Serum levels of IL-6, estrogen (E2) and bone gal protein (BGP) were determined by radioimmunoassay method. [Results] Serum level of IL-6 was higher in Group A and Group B than that in Group C and higher in Group A than that in Group B. A multiple regression analysis in Group B showed that IL-6 level was correlated negatively with BMD and estrogen, positively with BGP and had no correlation with age. [Conclusion] The pathogenesis of PMOP is related to the high level of IL-6 and the decrease of estrogen level.