通腑泻热灌肠剂对急腹症脓毒症术后血清C-反应蛋白的影响

Effect of Prescription of Dredging Intestines to Dispel Heat for Enema on Postoperative Serum C-reactive Protein Content in Acute Abdomen Induced by Pyemia

[目的]研究中药通腑泻热灌肠剂(由大黄、龙胆草、桅子、忍冬藤、虎杖、地胆头、莱菔子、芒硝等中药组成)对急腹症脓毒症患者的血清炎性介质C-反应蛋白(CRP)的影响。[方法]将57例急腹症脓毒症患者,随机分为治疗组(30例)和对照组(27例)两组,分别在西医常规手术及抗菌素治疗基础上给予通腑泻热灌肠剂和生理盐水灌肠治疗,观察两组治疗前后的血清C-反应蛋白含量变化及临床疗效,并作比较。[结果]两组均全部痊愈,治疗组在治疗后第7天血清C-反应蛋白含量明显下降,且与对照组比较有显著性差异(P<0.05),治疗组并发症发生率低于对照组。[结论]中药通腑泻热灌肠剂可降低急腹症脓毒症患者术后血清炎性介质C-反应蛋白含量,具免疫调节作用,能减轻该症术后的炎症反应及组织损害,提高临床疗效。

[Objective] To observe the effect of prescription of dredging intestines to dispel heat for enema on serum C-reactive protein content in acute abdomen (AA) induced by pyemia. [Methods] Fifty-seven cases of AA induced by py-emia were randomly allocated to two groups. On the basis of routine operation and application of antibiotics, Group A was treated with prescription of dredging intestines to dispel heat for enema and Group B with saline enema additionally. Therapeutic effect and C-reactive protein content in the two groups were observed and compared. [Results] All the cases in the two groups were cured. C-reactive protein content in Group A were decreased obviously in the 7th day after treatment (P <0.05 ) and the incidence of complications was lower than that in Group B. [Conclusion] Prescription of dredging intestines to dispel heat for enteroclysis is an effective and safe herbal medicine for AA induced by pyemia. It can reduce the inflammatory reaction and tissue damage by decreasing the inflammatory mediator of C-reactive protein.