摘要
目的 :评价国产厄贝沙坦对轻、中度原发性高血压的降压疗效及安全性。方法 :为双盲对照试验。轻、中度原发性高血压病人 40例 (男性 3 2例女性 8例 ,年龄 49a±s 1 0a)随机分为厄贝沙坦组和缬沙坦组各 2 0例 ,分别给予厄贝沙坦 1 5 0mg ,po,qd或缬沙坦 80mg ,po,qd ;2wk后按血压决定维持原剂量或厄贝沙坦增加到 3 0 0mg ,po,qd或缬沙坦增加为 1 60mg,po,qd;总疗程 4wk。结果 :厄贝沙坦治疗 4wk末的总有效率为 75 % ,收缩压下降 (2 .7± 1 .8)kPa,舒张压下降 (1 .5± 0 .8)kPa均P <0 .0 1 ;不良反应的发生率为 5 %。结论 :国产厄贝沙坦治疗轻、中度原发性高血压的短期疗效明显 ,每日服药 1次 ,疗效持久。
AIM: To evaluate the efficacy and safety of domestic irbesartan in treating essential hypertension. METHODS: Forty patients(M 32,F 8; age 49 a± s 10 a) with mild to moderate essential hypertension were divided randomly into irbesartan group ( n =20)and valsartan group ( n =20). They received irbesartan 150 mg, po , qd or valsartan 80 mg, po , qd in a double blind randomized parallel design. The doses were remained or increased to 300 mg, po,qd or 160 mg,po,qd after 2 wk treatment depending on the blood pressure. The total cause of treatment was 4 wk. RESULTS: At the end of 4 wk treatment with irbesartan, the total effective rate was 75 % , the systolic pressure decreased (2.7± 1.8) kPa, the diastolic pressure decreased (1.3± 0.8) kPa.The rate of adverse reaction was 5 %. CONCLUSION:The domestic irbesartan is obviously effective for mild to moderate essential hypertension in short treating period. Administration once per day will keep long and stable efficiency.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2002年第7期407-410,共4页
Chinese Journal of New Drugs and Clinical Remedies